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Bisphosphonates are a class of drugs widely used in the management of osteoporosis, and one of their key characteristics is their ability to inhibit bone resorption. This means they are effective in reducing the activity of osteoclasts, which are the cells responsible for breaking down bone tissue. By inhibiting this activity, bisphosphonates help to maintain or increase bone density and strength, thereby reducing the risk of fractures in individuals with osteoporosis.

The focus on inhibiting bone resorption rather than promoting osteoclast activity underscores the therapeutic approach of bisphosphonates. When bone resorption is decreased, the balance between bone formation and bone resorption is shifted towards bone formation, which is crucial for individuals at risk of losing bone mass.

The other characteristics mentioned in the question are not accurate in describing bisphosphonates. While many bisphosphonates can be administered orally, some are given intravenously, making it incorrect to state that they are administered orally only. Bisphosphonates do not promote osteoclast activity; rather, they directly inhibit it. Lastly, bisphosphonates do not increase blood calcium levels; in fact, they may cause a decrease in serum calcium levels due to their action on